کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7279811 | 1473900 | 2017 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses
ترجمه فارسی عنوان
دخالت گیرنده های نوع 1 اینترلوکین-1 در پاسخ های بیماری ناشی از لیپوپلی ساکارید
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Sickness responses to lipopolysaccharide (LPS) were examined in mice with deletion of the interleukin (IL)-1 type 1 receptor (IL-1R1). IL-1R1 knockout (KO) mice displayed intact anorexia and HPA-axis activation to intraperitoneally injected LPS (anorexia: 10 or 120 µg/kg; HPA-axis: 120 µg/kg), but showed attenuated but not extinguished fever (120 µg/kg). Brain PGE2 synthesis was attenuated, but Cox-2 induction remained intact. Neither the tumor necrosis factor-α (TNFα) inhibitor etanercept nor the IL-6 receptor antibody tocilizumab abolished the LPS induced fever in IL-1R1 KO mice. Deletion of IL-1R1 specifically in brain endothelial cells attenuated the LPS induced fever, but only during the late, 3rd phase of fever, whereas deletion of IL-1R1 on neural cells or on peripheral nerves had little or no effect on the febrile response. We conclude that while IL-1 signaling is not critical for LPS induced anorexia or stress hormone release, IL-1R1, expressed on brain endothelial cells, contributes to the febrile response to LPS. However, also in the absence of IL-1R1, LPS evokes a febrile response, although this is attenuated. This remaining fever seems not to be mediated by IL-6 receptors or TNFα, but by some yet unidentified pyrogenic factor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 66, November 2017, Pages 165-176
Journal: Brain, Behavior, and Immunity - Volume 66, November 2017, Pages 165-176
نویسندگان
Takashi Matsuwaki, Kiseko Shionoya, Robert Ihnatko, Anna Eskilsson, Shigeru Kakuta, Sylvie Dufour, Markus Schwaninger, Ari Waisman, Werner Müller, Emmanuel Pinteaux, David Engblom, Anders Blomqvist,