کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7281897 | 1473934 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Forced treadmill exercise training exacerbates inflammation and causes mortality while voluntary wheel training is protective in a mouse model of colitis
ترجمه فارسی عنوان
تمرینات تدریجی اجباری تشدید التهاب را ایجاد می کند و باعث مرگ و میر می شود در حالیکه آموزش داوطلبانه در اطراف یک مدل موس کولیت
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کلمات کلیدی
Stress - استرس یا فشار روانیColitis - التهاب روده بزرگinflammation - التهاب( توروم) Inflammatory bowel disease - بیماریهای التهابی رودهTreadmill running - تردمیل در حال اجرا استserum amyloid A - سرم آمیلوئید Adextran sodium sulphate - سولفات سدیم سدیمexercise - ورزشVoluntary wheel running - چرخ داوطلبانه در حال اجرا
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
The purpose of this study was to examine whether exercise training reduced inflammation and symptomology in a mouse model of colitis. We hypothesized that moderate forced treadmill running (FTR) or voluntary wheel running (VWR) would reduce colitis symptoms and colon inflammation in response to dextran sodium sulfate (DSS). Male C57Bl/6J mice were randomized to sedentary, moderate intensity FTR (8-12 m/min, 40 min, 6 weeks, 5x/week), or VWR (30 days access to wheels). DSS was given at 2% (w/v) in drinking water over 5 days. Mice discontinued exercise 24 h prior to and during DSS treatment. Colons were harvested on Days 6, 8 and 12 in FTR and Day 8 post-DSS in VWR experiments. Contrary to our hypothesis, we found that moderate FTR exacerbated colitis symptomology and inflammation as measured by significant (p < 0.05) increases in diarrhea and IL-6, IL-1β, IL-17 colon gene expression. We also observed higher mortality (3/10 died vs. 0/10, p = 0.07) in the FTR/DSS group. In contrast, VWR alleviated colitis symptoms and reduced inflammatory gene expression in the colons of DSS-treated mice (p < 0.05). While DSS treatment reduced food/fluid intake and body weight, there was a tendency for FTR to exacerbate, and for VWR to attenuate, this effect. FTR (in the absence of DSS) increased gene expression of the chemokine and antibacterial protein CCL6 suggesting that FTR altered gut homeostasis that may be related to the exaggerated response to DSS. In conclusion, we found that FTR exacerbated, whereas VWR attenuated, symptoms and inflammation in response to DSS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 33, October 2013, Pages 46-56
Journal: Brain, Behavior, and Immunity - Volume 33, October 2013, Pages 46-56
نویسندگان
Marc D. Cook, Stephen A. Martin, Collette Williams, Keith Whitlock, Matthew A. Wallig, Brandt D. Pence, Jeffrey A. Woods,