Mismatch negativity (MMN) reduction in schizophrenia-Impaired prediction-error generation, estimation or salience?

► We review 20 years of research on reduced mismatch negativity (MMN) in schizophrenia. ► What can the reduction in MMN can teach us about the pathophysiology of schizophrenia? ► We review the functional relevance of reduced MMN in schizophrenia. ► We note that MMN reflects the activity of a context-sensitive network. ► We require more knowledge about the role of network components and their modulators.