Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology

► Pctk1, Ccnd1 or Tcf12 overexpression all had an effect on learning and memory. ► Pctk1, Tcf12, and Ccnd1 in hippocampus produced spatial working memory deficits. ► Expression of Ccnd1 and Tcf12 produced spatial reference memory deficits. ► LTD induced by low frequency stimulation was absent in Pctk1 treated animals. ► Tcf12 also produced neurodegeneration and tumors in CA1 and dentate gyrus.