کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7302865 | 1475302 | 2016 | 67 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuregulin-1 and schizophrenia in the genome-wide association study era
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical component in the pathophysiology of schizophrenia. However, the arrival of the genome-wide association study (GWAS) era has yielded results that challenge the relevance of NRG1 in schizophrenia due to the absence of a genome-wide significant NRG1 variant associated with schizophrenia. To assess NRG1â¿¿s relevance to schizophrenia in the GWAS era, we provide a targeted review of recent preclinical evidence on NRG1â¿¿s role in regulating several aspects of excitatory/inhibitory neurotransmission and in turn schizophrenia risk. We also present a systematic review of the last decade of clinical research examining NRG1 in the context of schizophrenia. We include concise summaries of genotypic variation, gene-expression, protein expression, structural and functional neuroimaging as well as cognitive studies conducted during this time period. We conclude with recommendations for future clinical and preclinical work that we hope will help prioritize a strategy forward to further advance our understanding of the relationship between NRG1 and schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 68, September 2016, Pages 387-409
Journal: Neuroscience & Biobehavioral Reviews - Volume 68, September 2016, Pages 387-409
نویسندگان
Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P. Everall, Chad A. Bousman,