کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7303392 | 1475314 | 2015 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dyskinesias and impulse control disorders in Parkinson's disease: From pathogenesis to potential therapeutic approaches
ترجمه فارسی عنوان
اختلالات هاری و اختلالات کنترل ضربه در بیماری پارکینسون: از پاتوژنز تا رویکردهای درمانی بالقوه
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کلمات کلیدی
Impulse control disorders - اختلالات کنترل نفوذBehavioral addiction - اعتیاد رفتاریParkinson's disease - بیماری پارکینسونNeuroimaging - تصویربرداری عصبیDopaminergic drugs - داروهای دوپامینرژیکlevodopa-induced dyskinesias - دیسکینزی ناشی از لوودوپاbasal ganglia - عقدههای قاعدهایRisk factors - عوامل خطرPharmacology - فارماکولوژی یا داروشناسیNeurochemistry - نورو شیمیPathophysiology - پاتوفیزیولوژیGenetics - ژنتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Dopaminergic treatment in Parkinson's disease (PD) reduces the severity of motor symptoms of the disease. However, its chronic use is associated with disabling motor and behavioral side effects, among which levodopa-induced dyskinesias (LID) and impulse control disorders (ICD) are the most common. The underlying mechanisms and pathological substrate of these dopaminergic complications are not fully understood. Recently, the refinement of imaging techniques and the study of the genetics and molecular bases of LID and ICD indicate that, although different, they could share some features. In addition, animal models of parkinsonism with LID have provided important knowledge about mechanisms underlying such complications. In contrast, animal models of parkinsonism and abnormal impulsivity, although useful regarding some aspects of human ICD, do not fully resemble the clinical phenotype of ICD in patients with PD, and until now have provided limited information. Studies on animal models of addiction could complement the previous models and provide some insights into the background of these behavioral complications given that ICD are regarded as behavioral addictions. Here we review the most relevant advances in relation to imaging, genetics, biochemistry and pharmacological interventions to treat LID and ICD in patients with PD and in animal models with a view to better understand the overlapping and unique maladaptations to dopaminergic therapy that are associated with LID and ICD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 56, September 2015, Pages 294-314
Journal: Neuroscience & Biobehavioral Reviews - Volume 56, September 2015, Pages 294-314
نویسندگان
Haritz Jiménez-Urbieta, Belén Gago, Patricia de la Riva, Manuel Delgado-Alvarado, Concepció Marin, MarÃa C. Rodriguez-Oroz,