Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework

• Metal organic framework, Cu-TDPAT was synthesized.
• Cu-TDPAT was functionalized with NO forming a diazeniumdiolate.
• Cu-TDPAT releases NO upon exposure to 85% humidity and heat (37 °C).
• Cu-TDPAT adsorbs NO resulting in a distinct color change.

Metal–organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H6TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 μmol/g NO by exposure to 85% humidity and 53 μmol/g NO by heating to 37 °C.

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