Revisiting causal neighborhood effects on individual ischemic heart disease risk: A quasi-experimental multilevel analysis among Swedish siblings

► We study neighborhood (SAMS) effects on ischemic heart disease (IHD) risk. ► We compare IHD-risk in brothers with unlike exposure to neighborhood disadvantage. ► We found a small association but we cannot completely exclude residual confounding. ► We performed a multilevel (individuals, families, SAMS) analysis of variance. ► The variance analysis revealed the Swedish SAMS as irrelevant socio-geographic constructs.