کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
75169 | 49110 | 2010 | 10 صفحه PDF | دانلود رایگان |

A series of nanoporous silica matrices (a silica gel matrix and two ordered mesoporous silica) have been investigated as potential carriers for the controlled release of metoprolol tartrate a selective β1 receptor blocker used in the treatment of several diseases of the cardiovascular system. Particular attention was devoted to the optimisation of a reproducible and fast synthetic procedure. The textural properties, structure and chemical nature of the porous surfaces were characterised by N2 physisorption, X-ray diffraction, HR-TEM and FTIR analyses. The delivery profiles were collected in vitro in physiological solution at pH 7.4.It has been possible to observe a close correlation between the drug release kinetic and the textural properties of the carriers.
Journal: Microporous and Mesoporous Materials - Volume 132, Issues 1–2, July 2010, Pages 258–267