کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
75169 49110 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controlled release of metoprolol tartrate from nanoporous silica matrices
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Controlled release of metoprolol tartrate from nanoporous silica matrices
چکیده انگلیسی

A series of nanoporous silica matrices (a silica gel matrix and two ordered mesoporous silica) have been investigated as potential carriers for the controlled release of metoprolol tartrate a selective β1 receptor blocker used in the treatment of several diseases of the cardiovascular system. Particular attention was devoted to the optimisation of a reproducible and fast synthetic procedure. The textural properties, structure and chemical nature of the porous surfaces were characterised by N2 physisorption, X-ray diffraction, HR-TEM and FTIR analyses. The delivery profiles were collected in vitro in physiological solution at pH 7.4.It has been possible to observe a close correlation between the drug release kinetic and the textural properties of the carriers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microporous and Mesoporous Materials - Volume 132, Issues 1–2, July 2010, Pages 258–267
نویسندگان
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