Evaluation of matrix effect in isotope dilution mass spectrometry based on quantitative analysis of chloramphenicol residues in milk powder

- We develop a strategy to evaluate matrix effect and its impact on the IDMS results.
- Matrix effect and IDMS correction factor from different conditions are evaluated.
- Ion suppression effect is observed in LLE and HLB pre-treated sample solutions.
- Ion enhancement effect is found in MCX pre-treated sample solution.
- IDMS correction factor in HLB and MCX solutions in three instruments is close to 1