Elongin C is a mediator of Notch4 activity in human renal tubule cells

► Notch4ICD acts in concert with TGF-β pathway to drive fibrotic signaling. ► Proteomics studies indicate Notch4ICD and elongin C interact. ► Functional studies show elongin C inhibits Notch4-mediated TGF-β fibrotic activity. ► Elongin C negatively regulates Notch4ICD in a proteasome dependent manner. ► Elongin C is minimally expressed in type 1 diabetic renal proximal tubule cells.