کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7585230 | 1492035 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety assessment of sodium acetate, sodium diacetate and potassium sorbate food additives
ترجمه فارسی عنوان
ارزیابی ایمنی از استات سدیم، دی سکته سدیم و افزودنی های مواد غذایی پتاسیم سورباتی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Cytotoxicity and genotoxicity of sodium acetate (SA), sodium diacetate (SDA), and potassium sorbate (PS) was tested on Human Umbilical Vein Endothelial Cells (HUVEC). Cytotoxicity was investigated by MTT assay and flow cytometry analysis, while genotoxicity was evaluated using DNA fragmentation and DAPI staining assays. The growth of treated HUVECs with various concentrations of SA, SDA and PS decreased in a dose-and time-dependent manner. The IC50 of 487.71, 485.82 and 659.96â¯ÂµM after 24â¯h and IC50 of 232.05, 190.19 and 123.95â¯ÂµM after 48â¯h of treatment were attained for SA, SDA and PS, respectively. Flow cytometry analysis showed that early and late apoptosis percentage in treated cells was not considerable. Also neither considerable DNA fragmentation nor DNA smear was observed using DAPI staining and DNA ladder assays. Overall, it can be concluded that the aforementioned food additives can be used as safe additives at low concentration in food industry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 257, 15 August 2018, Pages 211-215
Journal: Food Chemistry - Volume 257, 15 August 2018, Pages 211-215
نویسندگان
Hossein Mohammadzadeh-Aghdash, Yousef Sohrabi, Ali Mohammadi, Dariush Shanehbandi, Parvin Dehghan, Jafar Ezzati Nazhad Dolatabadi,