کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7593563 | 1492118 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production
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کلمات کلیدی
tetramethylsilaneCDCl3TMSDMSO - DMSOUltraviolet - اشعه فرابنفشDimethyl sulfoxide - دیمتیل سولفواکسیدcircular dichroism - رنگ تابی دورانیRetention time - زمان بازداریInfrared - مادون قرمز (فروسرخ)Methanol - متانولMeOH - مونColumn chromatography - کروماتوگرافی ستونDeuterated chloroform - کلروفرم deuterated
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Five new 8-O-4Ⲡtype neolignans, named myrifralignan A-E (1-5), together with five known analogues (6-10), were isolated from the seeds of Myristica fragrans Houtt. Their chemical structures were determined using several spectroscopic methods. Compounds 3-10 exhibited potent inhibitory activity against the production of nitric oxide (NO) in the RAW264.7 cell line stimulated by lipopolysaccaride. Myrislignan (7) and machilin D (10) were the most potent inhibitors of NO production amongst these compounds. The IC50 values of myrislignan and machilin D were 21.2 and 18.5 μM. And, their inhibitory activity was more than L-N6-(1-iminoethyl)-lysine, a selective inhibitor of inducible nitric oxide synthase (IC50 = 27.1 μM). Furthermore, real-time PCR analysis revealed that these neolignans could significantly suppress the expression of inducible nitric oxide synthase mRNA. These results demonstrated that the 8-O-4Ⲡtype neolignans are promising candidates as anti-inflammatory agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 173, 15 April 2015, Pages 231-237
Journal: Food Chemistry - Volume 173, 15 April 2015, Pages 231-237
نویسندگان
Gui-Yun Cao, Wei Xu, Xiu-Wei Yang, Frank J. Gonzalez, Fei Li,