کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7607620 | 1493362 | 2018 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rate constant determination of interconverting enantiomers by chiral chromatography using a stochastic model
ترجمه فارسی عنوان
با استفاده از یک مدل تصادفی، تعیین ثابت انانتیومورهای متقاطع را با استفاده از کروماتوگرافی کروی انجام دهید
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کلمات کلیدی
تئوری اتفاقی، انانتیومرها، تعامل تعیین نرخ ثابت،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
A novel stochastic model was derived which takes both the separation and the interconversion into account at the molecular level - thus the effects of the parameters affecting the separation can be investigated. The novel model was used for the study of quetiapine, a drug molecule that interconverts during the separation to evaluate the rate constant based on the enantiomerization. Various flow rates and temperatures were used, and good agreement was obtained with the rate constant obtained from optical rotation experiments and with the software written by Trapp [1]. The most important result we concluded is the need of mild conditions during the separation to ascertain the rate constant the most accurately (low flow rates and temperatures where the enantiomerization process is limited to a few interconversions). The comparison of the rate constants of the on-column and the off-column experiments should be done by considering the stationary phase effects that are absent in the off-column experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1564, 24 August 2018, Pages 155-162
Journal: Journal of Chromatography A - Volume 1564, 24 August 2018, Pages 155-162
نویسندگان
Annamária Sepsey, Dóra Rita Németh, Gábor Németh, Attila Felinger,