Determination of isothiazolinone preservatives in cosmetics and household products by matrix solid-phase dispersion followed by high-performance liquid chromatography-tandem mass spectrometry

► MSPD-LC-MS/MS is implemented for the first time for isothiazolinone analysis. ► Successful application in cosmetics and house-hold products. ► The method is simple, rapid, low cost, and easy to implement for routine control. ► Isothiazolinone levels were quite high although legal limits were mostly fulfilled.