Comparison of four extraction methods for the determination of fungicide residues in grapes through gas chromatography-mass spectrometry

► MAE, MSPD, SLE and QuEChERS were optimized and tested for the extraction of pesticides in grapes. ► MAE, MSPD and SLE were optimized by experimental design. ► Linearity, LODs and LOQs, recoveries and precision of the four methods were compared. ► The methods were carried out for the analysis of spiked and real samples. ► MAE demonstrated to be more sensitive and faster than the other three methods.