Multiresidue determination of 375 organic contaminants including pesticides, polychlorinated biphenyls and polyaromatic hydrocarbons in fruits and vegetables by gas chromatography-triple quadrupole mass spectrometry with introduction of semi-quantificatio

► A GC-MS/MS method reported for multiresidue estimation of 349 pesticides, 11 PCBs and 15 PAHs. ► Method validated in grape, pomegranate, okra, tomato and onion matrices. ► All 375 compounds had LOQ < 10 μg/L with recoveries 70-110%. ► A semi-quantitative approach introduced with accuracies within ±10% of the values obtained by direct quantification. ► The method offers targeted screening and quantification capabilities.