Stir bar sorptive extraction and high performance liquid chromatographic determination of carvedilol in human serum using two different polymeric phases and an ionic liquid as desorption solvent

► We use of a novel polar sorptive phase for extraction of carvedilol using SBSE method. ► We examine an ionic liquid on the desorption step of SBSE for the first time. ► Adding ionic liquid increases extraction efficiency and eliminate memory effect. ► The high speed and simple treatment of proposed method are main advantages. ► The obtained detection limit is in the range of therapeutic level of carvedilol.