Multiple, simultaneous, independent gradients for versatile multidimensional liquid chromatography. Part I: Theory

► Algorithms for simultaneous independent gradients (SIGs) of ≥2 solutes in HPLC. ► Algorithms for SIGs of ≥1 solutes plus pH (SIGspH) in HPLC. ► Theoretical comparison of SIGspH and salt elution in ion exchange chromatography.