کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7614845 | 1493976 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Untargeted lipidomics based on UPLC-QTOF-MS/MS and structural characterization reveals dramatic compositional changes in serum and renal lipids in mice with glyoxylate-induced nephrolithiasis
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کلمات کلیدی
glycerophosphoserineSphingoid basesfatty acylUPLC-QTOF-MS/MSLPEFFAmonoacylglycerolLPCSterol - استرولsphingomyelin - اسفنگومیلینBile acid - اسید صفراویFree fatty acid - اسید چرب آزادinflammation - التهاب( توروم) triacylglycerol - تری آسیل گلیسرول Oxidative stress - تنش اکسیداتیوdiacylglycerol - دیسیل گلیسیرینCer - سرceramide - سرامیدLipidomics - لیپیدومیکسCAR - ماشینNephrolithiasis - نفروتیلاسیون یا سنگ کلیهCardiolipin - کاردیولیپینCarnitine - کارنیتینGlycerophosphate - گلیسروفسفاتglycerophosphoethanolamine - گلیسروفسفاتانولامینGlycerophosphoinositol - گلیسروفسفونیویتولglycerophosphocholine - گلیسروفسفوکولینglycerophosphoglycerol - گلیسروفسفوگلیسیرین
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Untargeted lipidomics based on UPLC-QTOF-MS/MS and structural characterization reveals dramatic compositional changes in serum and renal lipids in mice with glyoxylate-induced nephrolithiasis Untargeted lipidomics based on UPLC-QTOF-MS/MS and structural characterization reveals dramatic compositional changes in serum and renal lipids in mice with glyoxylate-induced nephrolithiasis](/preview/png/7614845.png)
چکیده انگلیسی
Nephrolithiasis is a systemic metabolic disease with a worldwide incidence that is increasing yearly, as well as a high recurrence rate; however, this disease's pathogenesis has not been thoroughly elucidated to date. Several epidemiological studies have shown that the risk for developing kidney stones increases in people with dyslipidemia. To explore the mechanism of lipid-induced kidney stones, we established a mouse model for renal urolithiasis based on intraperitoneal injections of glyoxylate (120â¯mg/kg/d). Lipidomics based on ultra high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC-QTOF-MS/MS) was performed to determine the changes in lipid metabolism in serum and kidneys. We screened 179 and 196 different lipid metabolites in the kidneys and serum, respectively, including fatty acyls, glycerophospholipids, sphingolipids, glycerolipids and prenol lipids. We found that polyunsaturated fatty acids, such as arachidonic acid, eicosapentaenoic acid, and docosahexoenoic acid, and ceramides and lysophosphocholines mediated inflammatory responses and that the oxidative stress induced by oleylethanolamine and glycerophosphoethanolamine plasmalogens is closely related to the development of kidney stones. These results provide strong evidence for the relationship between lipid metabolism and the development of kidney stones and suggest a clear direction for future research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 1095, 15 September 2018, Pages 258-266
Journal: Journal of Chromatography B - Volume 1095, 15 September 2018, Pages 258-266
نویسندگان
Yufan Chao, Songyan Gao, Xuelei Wang, Na Li, Hongxia Zhao, Xiaofei Wen, Ziyang Lou, Xin Dong,