کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622540 | 1494525 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of chlorogenic acid against aluminium neurotoxicity in ICR mice through chelation and antioxidant actions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Aluminium (Al), a potent neurotoxin, can induce oxidative stress and cause cognitive damage, which are associated with Alzheimer's disease. To investigate whether chlorogenic acid (CGA) may influence Al-induced neurotoxicity, aluminium chloride (35â¯mg Al/kg/day, i.g.) was chronically administered in mice pre-supplemented with CGA (50, 100 and 200â¯mg CGA/kg/day, i.g.) for 42 days. The results show that CGA attenuated Al-induced memory impairment, Al3+ accumulation, oxidative stress, mitochondrial damage, and nuclear pyknosis in the hippocampus. Administration of CGA remarkably promoted the antioxidant activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase and attenuated the rate of ATP hydrolysis. The antioxidant action of CGA could protect neurons against Al-induced oxidative stress by increasing the expression of nuclear factor-E2-related factor and its target phase II enzymes. Our findings show that CGA exhibits neuroprotective effects against Al-induced cognitive dysfunction through chelation and antioxidant actions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 365-376
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 365-376
نویسندگان
Xiaomei Wang, Yu Xi, Xiangquan Zeng, Handong Zhao, Jiankang Cao, Weibo Jiang,