کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622726 | 1494525 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling Hypouricemic effect of Grifola frondosa on hyperuricemic mice and virtual screening of bioactives by 3D QSAR pharmacophore modeling](/preview/png/7622726.png)
چکیده انگلیسی
Grifola frondosa (GF) has been exploited as herb medicine for metabolic diseases and also as tasty food in Asia. Water (GFW) and ethanol (GFE) extracts produced remarkable hypouricemic effects, thereby decreasing the levels of serum uric acid from 240â¯Î¼mol/L (hyperuricemia control, Pâ¯<â¯.01) to 170, 169, and 153â¯Î¼mol/L for GFW at doses of 30, 60, and 120â¯mg/kg and to 169, 168, and 156â¯Î¼mol/L for GFE at 50, 100, and 200â¯mg/kg correspondingly, which were similar to the normal control (159â¯Î¼mol/L). ELISA analysis demonstrated the inhibitory effects of GFW and GFE on URAT1 protein rather than xanthine oxidase (XOD). The 3D-QSAR pharmacophore model for URAT1 was established successfully. Four compounds were identified and mapped adequately, deserving further study. Taken together, G. frondosa is a promising candidate for the development of functional foods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 582-588
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 582-588
نویسندگان
Tianqiao Yong, Yizhen Xie, Shaodan Chen, Diling Chen, Jiyan Su, Chunwei Jiao, Huiping Hu, Chun Xiao,