کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622856 | 1494525 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses
ترجمه فارسی عنوان
جینسنگ قرمز کره ای، اختلال عملکرد بیضه ناشی از دوکسوروبیسین را در موش های صحرایی کاهش می دهد، با تعدیل پاسخ های التهابی، اکسیداتیو و اتوفایگی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The effect of Korean red ginseng (KRG; Panax ginseng Meyer) against doxorubicin (DOX)-induced testicular inflammation was investigated. Male Sprague-Dawley rats were treated with DOX (1â¯mgâ¯mLâ1â¯kgâ1â¯weekâ1; intra-peritoneally) for 8â¯weeks, and KRG water extract (EX1; 100 and EX2; 200â¯mg/kg/day; orally) was administered for 9â¯weeks starting one week before DOX exposure. The expression levels related to spermatogenesis, inflammatory and autophagy markers were evaluated using western blotting and reverse transcriptase polymerase chain reaction. DOX-induced a significant (pâ¯<â¯.05) alteration in the expression of antioxidation spermatogenesis and sex hormone receptors genes when compared with control groups, which were attenuated with KRG-WE treatment significantly (pâ¯<â¯.05â¯â¼â¯pâ¯<â¯.01). KRG-WE also ameliorated the DOX-induced alteration in pro-inflammatory cytokines via the mitogen-activated protein kinases/nuclear factor kappa-B pathway and autophagy in the testes of rats. In conclusion, KRG might be used as a functional food for prevention of chemotherapy-induced testicular inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 736-743
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 736-743
نویسندگان
Kyu-Min Cha, Spandana Rajendra Kopalli, Sang Yun Han, Sang-Ho Lee, Min-Sik Jeong, Jae Youl Cho, Chang-Gyun Han, Seung-Ho Lee, Soo-Nam Kim, Jin-Chul Kim, Si-Kwan Kim,