کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623631 | 1494546 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary Phaseolus vulgaris extract alleviated diet-induced obesity, insulin resistance and hepatic steatosis and alters gut microbiota composition in mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Haematoxylin (PubChem CID: 442514)Ethanol (PubChem CID: 702) - اتانول (PubChem CID: 702)Hepatic steatosis - استئاتوز کبدیIsopropanol (PubChem CID: 3776) - ایزوپروپانول (PubChem CID: 3776)Methanol (PubChem CID: 887) - متانول (PubChem CID: 887)Obesity - مرض چاقیInsulin resistance - مقاومت به انسولینGut microbiota - میکروبی خوب استChloroform (PubChem CID: 6212) - کلروفرم (PubChem CID: 6212)Glucose (Pubchem CID: 5793) - گلوکز (Pubchem CID: 5793)
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Phaseolus vulgaris may reduce appetite, body weight and gut microbiota and has been shown to contribute to the development of obesity, type 2 diabetes and non-alcoholic fatty liver disease. This study was conducted to investigate the impact of P.âvulgaris extract (PVE) on obesity and obesity-associated metabolic syndromes, and determine whether the protective effects of PVE were associated with modulation of gut microbiota. C57BL/6J mice were fed low-fat diet, high-fat diet or high-fat diet supplemented with PVE of 50âmg/kg. The composition of gut microbiota was analysed by 16S rDNA sequencing. Our results showed that PVE treatment reduced body weight and improved hepatic steatosis and insulin resistance in high-fat diet-fed mice. PVE administration increased the relative abundance of Bifidobacterium, Lactobacillus and Akkermansia at the genus level. In conclusion, PVE protects from diet-induced obesity, insulin resistance and hepatic steatosis, and these beneficial effects were associated with the PVE-related modulation of gut microbiota.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 236-244
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 236-244
نویسندگان
Haizhao Song, Wen Han, Fujie Yan, Dongdong Xu, Qiang Chu, Xiaodong Zheng,