کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624514 | 1494547 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production](/preview/png/7624514.png)
چکیده انگلیسی
The contribution of Gordonibacter to the different abilities, both qualitative and quantitative, of individuals to transform dietary ellagic acid into anti-inflammatory urolithins was investigated. A specific and suitable q-PCR system was developed for the detection and quantification of Gordonibacter. Ellagic acid metabolism in the gut and faecal microbiota of healthy individuals, who consumed walnuts (nâ=â20) or a pomegranate extract (nâ=â49), were studied. Urolithin-A was positively correlated to Gordonibacter in faeces, whereas excretion of isourolithin-A and/or urolithin-B was inversely correlated to both. The relationship between Gordonibacter and urolithin-A found in vivo was also confirmed in vitro. This suggests that the beneficial effects attributed to the consumption of foods containing ellagic acid could be mediated by the individuals' Gordonibacter levels. The development of prebiotics, probiotics or synbiotic aimed at increasing Gordonibacter and related species could improve the individual's ability to produce the anti-inflammatory, cardioprotective and anticancer metabolite urolithin-A.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 785-791
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 785-791
نویسندگان
MarÃa Romo-Vaquero, RocÃo GarcÃa-Villalba, Antonio González-SarrÃas, David Beltrán, Francisco A. Tomás-Barberán, Juan C. EspÃn, MarÃa V. Selma,