Complementary and alternative medicinal effects of broccoli sprouts powder on Helicobacter pylori eradication rate in type 2 diabetic patients: A randomized clinical trial

The effectiveness of high-sulforaphane broccoli sprouts powder, as both complementary and alternative treatment, was compared to the standard triple therapy on Helicobacter pylori eradication in type 2 diabetic patients. Eighty-six type 2 diabetic patients with positive H. pylori stool antigen test (HpSAg) were randomized to receive one of the three following regimens: (STT) standard triple therapy, (BSP) 6 g/d broccoli sprouts powder for 28 days, and combination of these as STT + BSP. H. pylori eradication rates were assessed both by HpSAg and the urea breath test (UBT). Fasting serum glucose, insulin, insulin resistance, pepsinogen (PG) I and II levels and PGI/II ratio were also assessed. The H. pylori eradication rates, as assessed by UBT and HpSAg, were 85.3% and 89.3% in STT, 36.0% and 56.0% in BSP, and 83.3% and 91.7% in STT + BSP groups, respectively. There were no significant differences in serum pepsinogen I, pepsinogen II and PGI/PGII ratio and glucose homeostasis parameters between the three groups. BSP regimen despite a considerable effect on H. pylori eradication could not compete with the standard triple therapy.