کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7625540 1494558 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of azoxymethane-induced preneoplastic lesions in the rat colon by a stearic acid complexed high-amylose cornstarch using different cooking methods and assessing potential gene targets
ترجمه فارسی عنوان
مهار ضایعات پیش پپتیدی ناشی از آسکسی متیان در کولون موش با استفاده از اسید استئاریک پودر ذرت بالا آمیلوز با استفاده از روش های مختلف پخت و پز و ارزیابی اهداف بالقوه ژن
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Stearic-acid-complexed-high-amylose-cornstarch (SAC) prevented preneoplastic lesions in the colon of azoxymethane (AOM)-treated Fisher344 rats fed cooked SAC for 8 weeks when water-boiling or bread-baking cooking methods were applied. Water-boiled-SAC (w-SAC) diet was compared with water-boiled-control-cornstarch (w-CS) or water-boiled-high-amylose-cornstarch (w-HA), and bread-baked-CS (b-CS) were compared with bread-baked-HA (b-HA) and bread-baked-SAC (b-SAC). Gene expression profiles from rats fed different water-boiled diets were determined. w-SAC or b-SAC markedly reduced pre-noeplasia compared with HA or CS. Increased cecal contents and decreased cecal pH were observed in SAC or HA groups. Total or individual (butyrate, acetate, and propionate) short-chain fatty acids (SCFAs) increased in selected SAC groups. Differentially expressed genes for AOM treatment were observed in rats fed w-CS and injected with AOM or saline (6428 genes), and for diet treatment in rats injected with AOM and fed w-CS or w-SAC (1403 genes). Changes in 7 genes (CACYBP, RhoA, MAPK1, TOPBP1, HSPH1, MCM6, and HSPD1) were confirmed with qRT-PCR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 6, January 2014, Pages 499-512
نویسندگان
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