Nuclear magnetic resonance spectroscopy as a tool for the quantitative analysis of water and ions in pharmaceuticals: Example of heparin

The quantitative data for a representative set of more than hundred Na- and Ca- heparin and low-molecular weight heparin (LMWH) samples were discussed regarding animal origin and the type of anticoagulant. NMR spectrometry represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of heparin.