کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7627130 1494581 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Silylation of acetaminophen by trifluoroacetamide-based silylation agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Silylation of acetaminophen by trifluoroacetamide-based silylation agents
چکیده انگلیسی
In the presented report, we have described the silylation reaction between the amide group in acetaminophen and a two most popular trifluoroacetamide-based silylation reagents - BSTFA and MSTFA. Both reagents had a amide groups on structures. An investigation was made through the performance of a set of experiments, GC-MS analysis, and a theoretical study, namely interpretation of mass spectra, presentation of the resonance states of all the involved compounds and SN2 reaction schemes, which was found to be different when BSTFA and MSTFA was applied. The negligible effect of used solvent was also described. The fragmentation of TMS-derivatives (MS spectra) was presented and it has confirmed our previous investigations with silylation of pharmaceuticals, and a general rules of fragmentation patterns. Thanks to this the structure of di-O,O-TMS-acetaminophen was proven.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 154, 30 May 2018, Pages 433-437
نویسندگان
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