کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7627468 | 1494588 | 2018 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circular dichroism in functional quality evaluation of medicines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Circular dichroism (CD) is a non-destructive and powerful technique for providing structure and ligand interaction information of small molecules as well as biotechnological medicines. While CD is a well-established technique in biomedical research, and different types and variants of CD do exist, the focus of this review is on the pharmaceutical quality control (QC) aspects of the classic electronic CD (ECD). The basic principles of the CD technique are initially described, followed by a systematic literature research on pharmaceutical aspects encompassing chiral small molecules, bio-polymers (i.e. proteins, peptides and nucleic acids), medicine-biotarget interaction (i.e. small molecule-albumin interaction, protein-receptor interaction and peptide-biotarget interaction) and medicine changes (i.e. chemical modification, biosimilar/bio-better with stability and aggregation). In addition, unstructured literature was also included covering the use of CD mainly in discovery and fundamental research, but which might shift towards the pharmaceutical QC field as well in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 147, 5 January 2018, Pages 50-64
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 147, 5 January 2018, Pages 50-64
نویسندگان
Han Yao, Evelien Wynendaele, Xiaolong Xu, Anne Kosgei, Bart De Spiegeleer,