Vibrational and thermal analyses of multicomponent crystal forms of the anti-HIV drugs lamivudine and zalcitabine

- Vibrational and thermal profiles of the high-solubility lamivudine crystal forms.
- Raman spectra sensible to both drug conformation and supramolecular architecture.
- 5′-CH2OH conformation driving intramolecular hydrogen bond formation and Raman band.
- DFT spectra: coupling of aromatic CH stretchings depending on 5′-CH2OH conformation.
- DSC and TG prove crystal stoichiometry found from X-ray diffraction structure.