Determination of isobavachalcone in rat plasma by LC-MS/MS and its application to a pharmacokinetic study

- We developed an LC-MS/MS method for determination of isobavachalcone in plasma.
- The LC-MS/MS method showed good linearity, sensitivity, precision, and specificity.
- The new method was applied to a pharmacokinetic study of isobavachalcone in rats.
- This is the first study of oral isobavachalcone pharmacokinetics.