کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7629933 1645359 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study on the pharmacokinetics profiles of Polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC-MS/MS method
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Study on the pharmacokinetics profiles of Polyphyllin I and its bioavailability enhancement through co-administration with P-glycoprotein inhibitors by LC-MS/MS method
چکیده انگلیسی

- Pharmacokinetics of Polyphyllin I (PPI) was study by LC-MS/MS method.
- The bioavailability of PPI is about 0.62% after oral administration.
- P-gp inhibitors decrease efflux ratio of PPI in Caco-2 cell model.
- P-gp inhibitors increase intracellular concentration of PPI in Caco-2 cell model.
- P-gp inhibitors could enhance the oral bioavailability of PPI in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 107, 25 March 2015, Pages 119-124
نویسندگان
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