Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease

- Serum metabolic profiles of APP/PS1 mice were characterized by combined ESI/APPI-MS.
- Alterations in energy metabolites, amino acids and lipids were detected.
- APP/PS1 mice allow studying pathological mechanisms as model of Alzheimer disease.