Enhanced intra-cutaneous delivery of a Mn-containing antioxidant drug by high-frequency ultrasounds

- A MnII complex with anti-inflammatory properties targets the upper dermal layers.
- Transfer of the MnII complex to the fluid of the acceptor Franz cell is negligible.
- Ultrasound application enhances penetration into the epidermis.
- The MnII-based compound is a promising drug against inflammatory processes of skin.