Identification of hydrolytic and isomeric N-oxide degradants of vilazodone by on line LC-ESI-MS/MS and APCI-MS

- Identified a total of 7 hydrolytic and isomeric N-oxides degradants of vilazodone.
- Comprehensive characterization of all degradants using online UPLC-QTOF-MS/MS.
- Demonstrated an application of APCI-MS to characterize isomeric N-oxides degradants.
- Mechanistic explanation of vilazodone degradation demonstrated.