Metabolomic screening of regional brain alterations in the APP/PS1 transgenic model of Alzheimer's disease by direct infusion mass spectrometry

- Direct infusion mass spectrometry allows a comprehensive brain metabolomic analysis.
- The APP/PS1 mice exhibited an abnormal neurochemical profile compared to controls.
- These failures affected hippocampus, cortex, cerebellum and olfactory bulbs.
- Pathway analysis revealed multiple significant impairments in brain metabolism.