Development of an improved ligand exchange chiral stationary phase based on leucinol for the resolution of proton pump inhibitors

- A new ligand exchange chiral stationary phase (CSP) based on (S)-leucinol was prepared.
- The residual silanol groups of the CSP were protected with n-octyl groups.
- The new CSP was very successful in the resolution of proton pump inhibitors (PPIs).
- The separation (α) and resolution factor (RS) for omeprazole were 5.90 and 6.70, respectively.