Quantification of total and unbound tranexamic acid in human plasma by ultrafiltration liquid chromatography/tandem mass spectrometry: Application to pharmacokinetic analysis

- Rapid and sensitive method for determination of tranexamic acid concentration LC/MS/MS.
- Total and unbound tranexamic acid concentrations were measured after ultrafiltration.
- Tranexamic acid pharmacokinetic parameters were determined in patients undergoing orthopedic surgery.