کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7631255 1494647 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Overestimation of flavonoid aglycones as a result of the ex vivo deconjugation of glucuronides by the tissue β-glucuronidase
چکیده انگلیسی
Tissue β-glucuronidase hydrolyzes flavonoid glucuronides to their aglycones during tissue extraction, resulting in higher reported tissue levels of aglycone. β-Glucuronidase inhibitor d-saccharic acid 1,4-lactone (SL) blocks the ex vivo deconjugation of flavonoid glucuronides. SL at concentration of 15 μmol/g liver tissue decreases quercetin (Q) and methyl-quercetin (Me-Q) deconjugated from glucuronides by 87% and 84%, respectively (**p < 0.01).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 88, 25 January 2014, Pages 364-369
نویسندگان
, , , ,