Quantitative determination of Lx2-32c, a novel taxane derivative, in rat plasma by liquid chromatography-tandem mass spectrometry

- Lx2-32C, a novel taxane derivative, had significant antitumor activity.
- Lx2-32c had potent antiproliferative effect on several drug-resistant tumor cells.
- Quantitative determination method of Lx2-32C in rat plasma was developed.
- This method was useful for further characterizations of pharmacokinetics of Lx2-32c.