Analyses of marketplace tacrolimus drug product quality: Bioactivity, NMR and LC-MS

- Tacrolimus capsules from five sources have similar biological potencies.
- All tacrolimus products inhibit the calcineurin/IL-2 pathway with similar efficacies.
- Any ascomycin is below the detection limits of both NMR or LC-MS.
- No other literature predicted impurities were observed in the marketplace products.