Studies on separation and pharmacokinetics of m-nisoldipine enantiomers in beagle dog plasma by LC/MS/MS

- m-Nisoldipine enantiomers were determined by LC/MS/MS in beagle dog plasma.
- Chiral column was firstly used to analyze the sample in beagle dog plasma.
- A simple protein precipitation procedure was used.
- The pharmacokinetic parameters are no significant differences between enantiomers.