Metabonomic study on the biochemical response of spontaneously hypertensive rats to chronic taurine supplementation using 1H NMR spectroscopic urinalysis

- Chronic taurine treatment changed urinary metabolite profiles in hypertensive rats.
- Time-dependent metabolic changes occurred with a hypotensive effect.
- Metabolic acidosis was suggested with decreased citric acid cycle intermediates.
- The modulation of the intestinal microbial metabolism was observed.
- 1H NMR metabonomics of hypertensive rats was shown to be a promising approach.