LC-MS/MS method for the simultaneous quantitation of three active components derived from a novel prodrug against schistosome infection

- Simultaneous quantitation of three hydrolytic products from the prodrug DW-3-15.
- Excellent chromatographic resolution with a short run time.
- Specific and sensitive MS detection of ARS, DHA and 10-OHPZQ.
- Successful application to pharmacokinetic studies.
- Utility in mechanistic investigations on in vivo hydrolysis of the prodrug.