Hyaluronidases and their inhibitors in the serum of colorectal carcinoma patients

HYAL-1 activity in sera of CRC patients: Quantification of HYAL-1 activity (buffer pH 3.7) in sera obtained from normal population (N) and CRC patients one day before operation (D-1), one week (D + 7) and one year (D + Y) postoperatively. Single asterisk indicates statistical difference with normal population (p < 0.05). Double asterisk indicates statistical difference with sera obtained one day preoperatively (p < 0.01).