A rapid and sensitive liquid chromatography-tandem mass spectrometric assay for cycloserine in 50 μL of human plasma: Its pharmacokinetic application

► Most sensitive LC-MS/MS method for cycloserine. ► The method employs only 50 μL of plasma volume. ► The method utilized a single step protein precipitation procedure. ► Greater sensitivity. ► The total analysis time is shortest compared to all existing methods.