Tris(hydroxymethyl) aminomethane salt of ramipril: Synthesis, structural characterization from X-ray powder diffraction and stability studies

► X-ray powder structure of ramipril-tris salt. ► A comparison of solid-state stabilities of ramipril with ramipril salts. ► Ramipril-tris salt exhibits a better solution phase stability compared to that of ramipril. ► Ramipril-tris salt is expected to be a potential alternative of existing API ramipril in drug formulation.