Comparative proteome analysis reveals differential regulation of glycolytic and antioxidant enzymes in cortex and hippocampus exposed to short-term hypobaric hypoxia

► Proteomes of cortex and hippocampus under hypobaric hypoxia were investigated ► A total of 88 and 73 proteins for cortex and hippocampus were identified ► Upregulation of glycolytic and malate-aspartate shuttle enzymes were observed in cortex ► Higher levels of antioxidant enzymes were also observed in cortex ► Better energy production and antioxidant system makes cortex more hypoxia resistant