La spectrométrie de masse dans le contrôle antidopage

Anti-doping analysis is a very peculiar area of forensic toxicology, aimed at detecting, in urine and/or blood, substances (and methods) which are on a list of prohibited substances and methods published by the world anti-doping agency (WADA). These analyses are carried out by 34 laboratories accredited by WADA. Since mass spectrometry and its combination with chromatography become standard instrumentations at the end of 70ths, a large number of analyses are based on mass spectrometry. The challenge in this field consists in the research of a large number of substances and/or their metabolites, of very different chemical structures, in a limited sample volume and in a limited time, with a maximal of both sensitivity and specificity. Continuously new methods and approaches, developed in accordance with instrumentation innovations in mass spectrometry, are developed to increase the specificity and the sensitivity of the detection and expand the portfolio of detection procedures to substances of high molecular masses.